Matthew A. Boegehold, PhD

  • AU/UGA Medical Partnership

    Interim Campus Associate Dean for Curriculum and Chair of Basic Sciences

  • AU/UGA Medical Partnership

    Professor of Physiology

  • UGA College of Veterinary Medicine

    Professor of Physiology & Pharmacology

  • Medical College of Georgia at AU

    Professor of Physiology (adjunct)

Boegehold serves as Basic Science Chair for the AU/UGA Medical Partnership, and is also a Professor in the Department of Physiology and Pharmacology, University of Georgia College of Veterinary Medicine, and in the Department of Physiology, Medical College of Georgia. Boegehold earned his Ph.D. at the University of Arizona, and previously served as Director of the Center for Cardiovascular and Respiratory Sciences at West Virginia University.

Education

1980 BS Biology University of Michigan
1986 PhD Physiology University of Arizona

Residency

1986-1988 Postdoctoral training: Vascular Biology Indiana University School of Medicine

Academic Appointments

1988-1994 Assistant Professor of Physiology
1994-2000 Associate Professor of Physiology
2000-2013 Professor of Physiology
2001-2012 Vice Chair, Dept. of Physiology and Pharmacology
2003-2012 Founding Director
2012-2013 Director, Graduate Recruiting and Program Development
2014- Basic Science Chair
Professor of Physiology & Pharmacology
Professor of Physiology (adjunct)

More About Matthew Boegehold

Boegehold received his Ph.D. in Physiology from the University of Arizona, and, after a short postdoctoral fellowship at Indiana University, joined the faculty at West Virginia University School of Medicine in 1988.  At WVU, Boegehold established a productive, NIH-funded research program focused primarily on microvascular dysfunction associated with high salt intake and salt-sensitive hypertension.  Attracted by the prospect of working with others to develop new research and educational initiatives on a young medical campus, he joined the AU/UGA Medical Partnership as Basic Sciences Chair in January 2014.

Boegehold has published over 70 peer-reviewed articles and book chapters and has received numerous awards for his work in the field of vascular biology, including the Microcirculatory Society Outstanding Young Investigator Award and the WVU Dean’s Award for Excellence in Research.  Boegehold was elected President of the Microcirculatory Society in 2011.  He currently serves on the editorial board for the international journal “Microcirculation,” and he has served on numerous grant review panels for the National Institutes of Health and the American Heart Association.  He also served for nine years as Director of the WVU Center for Cardiovascular and Respiratory Research and as Director of Graduate Recruiting and Program Development for WVU Health Sciences Center.

Boegehold is highly devoted to medical education.  In addition to his previous work in medical curriculum development, he has taught medical students for more than 20 years. 

  • Expertise & Interests

    • Cardiovascular function in health and disease
    • Hypertension
    • Effect of air pollution on cardiovascular health
  • Research Interests

    • Neural and local regulation of microvascular tone and tissue blood flow.
    • Effect of growth, development and aging on microvascular function.
    • Vascular dysfunction linked to high dietary salt intake and salt-sensitive hypertension.
    • Vascular dysfunction following exposure to airborne particulates.
  • Selected Publications

    Boegehold MA. The effect of high salt intake on endothelial function: reduced nitric oxide in the absence of hypertension.  J Vasc Res 50: 458-467, 2013.

    Kang LS, Nurkiewicz TR, Wu G, Boegehold MA. Changes in eNOS phosphorylation contribute to increased arteriolar nitric oxide release during juvenile growth.  Am J Physiol Heart Circ Physiol 302: H560-H566, 2012.

    Nayeem MA, Zeldin DC, Boegehold MA, Falck JR. Salt modulates vascular response through adenosine A2A receptor in eNOS-null mice: role of CYP450 epoxygenase and  soluble epoxide hydrolase.  Mol Cell Biochem 350: 101-111, 2011.

    Balch Samora J, Goodwill AG, Frisbee JC, Boegehold MA.  Growth-dependent changes in the contribution of carbon monoxide to arteriolar function.  J Vasc Res 47:23-34, 2010.

    Nurkiewicz TR, Wu G, Li P, Boegehold MA.  Decreased arteriolar tetrahydrobiopterin is linked to superoxide generation from nitric oxide synthase in mice fed high salt. Microcirculation 17: 147–157, 2010.

    Nayeem MA, Zeldin D, Boegehold MA, Morisseau C, Marowsky A, Ponnoth D, Roush K, Falck J.  Modulation by salt intake of the vascular response mediated through adenosine A2A receptor: role of CYP epoxygenase and soluble epoxide hydrolase. Am J Physiol Reg Int Comp Physiol 299: R325-R333, 2010.

    Boegehold MA.  Endothelium-dependent control of vascular tone during early postnatal and     juvenile growth.  Microcirculation 17: 394-406, 2010.

    Nayeem MA, Ponnoth DS, Boegehold MA, Zeldin DC, Falck JR, Mustafa SJ.  High salt diet enhances mouse aortic relaxation through adenosine A2A receptor via CYP epoxygenases. Am J Physiol Reg Int Comp Physiol 296:R567-R574, 2009.

    Nurkiewicz TR, Porter DW, Hubbs AF, Stone S, Chen BT, Frazer DG, Boegehold MA, Castranova V.  Pulmonary nanoparticle exposure disrupts systemic microvascular nitric oxide signaling.  Toxicol Sci 110:191-203, 2009.

    Frisbee JC, Hollander JM, Brock RW, Yu HG, Boegehold MA. Integration of pathways for skeletal muscle arteriolar reactivity in the metabolic syndrome. Am J Physiol Reg Int Comp Physiol 296:R1771-R1782, 2009.

    Balch Samora J, Frisbee JC, Boegehold MA. Hydrogen peroxide emerges as a regulator of tone in skeletal muscle arterioles during juvenile growth.  Microcirculation 15: 151-161, 2008.                       

    Balch Samora J, Frisbee JC, Boegehold MA.  Increased myogenic responsiveness of skeletal muscle arterioles with juvenile growth.  Am J Physiol Heart Circ Physiol 294: H2344-H2351, 2008.

    Balch Samora J, Frisbee JC, Boegehold MA. Growth-dependent changes in endothelial factors regulating arteriolar tone. Am J Physiol Heart Circ Physiol 292: H207-H214, 2007.

    Marvar PJ, Falck JR, Boegehold MA.  High dietary salt reduces the contribution of 20-HETE to arteriolar oxygen responsiveness in skeletal muscle. Am J Physiol Heart Circ Physiol 292: H1507-H1515, 2007.

    Nurkiewicz TR, Boegehold MA. High salt intake reduces endothelium-dependent dilation of mouse arterioles via superoxide anion generated from nitric oxide synthase. Am J Physiol Reg Int Comp Physiol 292: R1550-R1556, 2007.

    Marvar PJ, Hammer LW, Boegehold MA.  Hydrogen peroxide-dependent arteriolar dilation in contracting muscle of rats fed normal and high salt diets. Microcirculation 14: 779-791, 2007.

    Nurkiewicz TR, Porter DW, Barger M, Millecchia L, Murali K, Rao KMK, Marvar PJ, Hubbs AF, Castranova V, Boegehold MA. Systemic microvascular dysfunction and inflammation after

    pulmonary particulate matter exposure. Environ Health Perspect 114: 412-419, 2006.

    Marvar PJ, Nurkiewicz TR, Boegehold MA. Reduced arteriolar responses to skeletal muscle contraction after ingestion of a high salt diet. J Vasc Res 42: 226-236, 2005.

    Hammer LW, Boegehold MA. Functional hyperemia is reduced in skeletal muscle of aged rats. Microcirculation 12: 517-526, 2005.

    Nurkiewicz TR, Boegehold MA. Calcium-independent release of endothelial nitric oxide in the arteriolar network: Onset during rapid juvenile growth. Microcirculation 11: 453-462, 2004.

    Nurkiewicz TR, Porter DW, Barger M, Castranova V, Boegehold MA. Particulate matter exposure impairs systemic microvascular endothelium-dependent dilation. Environ Health Perspect 112: 1299-1306, 2004.

  • Affiliations

    • Microcirculatory Society
    • American Physiological Society
    • American Heart Association Council on High Blood Pressure Research
    • Society of Toxicology
    • Association of Chairs of Departments of Physiology
    • International Association of Medical Science Educators
  • Of Note

    • Councilor, Cardiovascular Toxicology Specialty Section, Society of Toxicology, 2012
    • President, Microcirculatory Society, 2011-2012
    • Councilor, Microcirculatory Society, 2001
    • Fellow, Cardiovascular Section, American Physiological Society, 2001
    • Dean's Award for Excellence in Research, West Virginia University School of Medicine, 2000