Jaroslava Halper, MD, PhD

  • AU/UGA Medical Partnership

    Professor of Pathology

  • University of Georgia

    Professor, Department of Pathology

Jaroslava Halper, MD, PhD is a board-certified pathologist who trained at Albert Einstein College of Medicine in New York and the Mayo Clinic. She has been involved in growth factor and tissue repair research and is currently studying pathogenesis of several tendon disorders.

Education

1986 PhD Experimental Pathology University of Minnesota
1980 MD University of Toronto
1972-76 Transferred Medical School, Charles University, Prague, Czechoslovakia

Residency

1982-1986 Residency (Anatomic Pathology) Mayo Clinic, Rochester, MN
1980-1981 Albert Einstein College of Medicine, Bronx, New York

Academic Appointments

2011-Present Adjunct Professor, Department of Pathology, Medical College of Georgia, Georgia Health Sciences University, Augusta, GA, participates in Georgia Health Sciences University/University of Georgia Medical Partnership
2006-Present Membership in the Interdisciplinary Toxicology Program, The University of Georgia, Athens, Georgia
2006-Present Membership in the Biomedical and Health Sciences Institute, The University of Georgia, Athens, Georgia
2007-Present Professor, Department of Pathology, College of Veterinary Medicine, The University of Georgia, Athens, Georgia
1991-2007 Associate Professor, Department of Pathology, College of Veterinary Medicine, The University of Georgia, Athens, Georgia
2004 Visiting Scientist, Animal and Veterinary Research Institute, Shanghai Academy of Agricultural Sciences, Shanghai, China
1996 Visiting Scientist, Endocrine Laboratory, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada
1986-1991 Assistant Professor, Department of Pathology, College of Veterinary Medicine, The University of Georgia, Athens, Georgia
1985-1986 Research Associate, Department of Cell Biology, School of Medicine, Vanderbilt University, Nashville, Tennessee

More About Jaroslava Halper

Jaroslava Halper, MD, PhD started her medical studies at the venerable Charles University in Prague, Czech Republic and completed her medical degree at the University of Toronto. She decided to pursue pathology because of her desire to pursue basic medical research within the framework of medical problems.  She trained in pathology at Albert Einstein College of Medicine in New York City and the Mayo Clinic (and, eventually, became a Diplomat of the American Board of Pathology). During her residency training she entered a PhD program in Experimental Pathology. With Dr. Harold Moses as her major professor, she discovered and characterized a novel growth factor, called TGFe for promoting the growth of epithelial cell. This work was the basis for her dissertation.  She continued in this line of work when she joined faculty in the Department of Pathology at the College of Veterinary Medicine of the University of Georgia. Soon it was recognized that TGFe is the first described member of progranulins - a group of growth factors involved in wound healing and CNS function, to name just two of their physiological roles.  Since then, Halper has worked on further characterization of wound healing and of TGFe and TGFβ, and she became interested in tendon disorders. Her laboratory has studied the effect of enrofloxacin, a fluoroquinolone antibiotic closely related to Cipro, on biochemical integrity of avian and equine tendons in vitro and in vivo.  Halper has redefined and made significant advances in pathology and pathogenesis of an equine disease called degenerative suspensory ligament desmitis, a disorder similar to a rare form of Ehlers Danlos syndrome in people. Most recently she has enjoyed teaching pathology to medical students at the Medical Partnership.

  • Expertise & Interests

    • Tendon diseases
    • Growth factors
    • Wound healing
    • General Pathology
  • Selected Publications

    1. Yang YH, Ard MB, Halper JT, Barabino GA. 2014.  "Type I collagen-based fibrous capsule enhances integration of tissue-engineered cartilage with native articular cartilage." Annals Biomed Eng 42:716-726; doi: 10.1007/s10439-013-0958-4.
    2. Halper J (editor and author of four chapters).  Progress in Heritable Soft Connective Tissue Diseases.  Series: "Advances in Experimental Medicine and Biology," Springer SBM, Dordrecht, The Netherlands, 2014.
    3. Kim B, Yoon JH, Zhang J, Mueller POE, Halper J. 2010. "Glycan profiling of a defect in decorin glycosylation in equine systemic proteoglycan accumulation, a potential model of progeroid form of Ehlers-Danlos syndrome." Arch Biochem Biophys, 501:221-231.
    4. Halper J.  2010. "Growth factors as active participants in carcinogenesis: a perspective."  Invited review.  Veterinary Pathology 47:77-97.
    5. Sousa R, Halper J, Zhang J, Lewis SJ, Li WIO. 2008.  "Effect of Lactobacillus acidophilus supernatants on body weight and leptin expression in rats."  BMC Complementary and Alternative Medicine 8:5.
    6. Foutz T, Ratterman A, Halper J. 2007. "Effects of immobilization on the biomechanical properties of broiler tibia and gastrocnemius tendon."  Poultry Science 86:931-936.
    7. Foutz TL, Griffin AK, Halper JT, Rowland GN.  2007. "Effects of increased physical activity on juvenile avian bone."  Transactions of the ASABE. 50(1): 213-219.
    8. Foutz TL, Griffin AK, Halper JT, Rowland GN. 2007. "Effects of activity on avian gastrocnemius tendon."  Poultry Science 86:211-218.
    9. Halper J, Kim B, Khan A, Yoon JH, Mueller POE. 2006. "Degenerative suspensory ligament desmitis as a systemic disorder characterized by proteoglycan accumulation."  Biomed Central Veterinary Research 2:12.
    10. Yoon JH, Halper J. 2005. "The quantification of chondroitin sulfate by rocket electrophoresis." Anal. Biochem. 344: 158-160.
    11. Li WI, Brackett BG, Halper J. 2005. "Culture supernatant of Lactobacillus acidophilus stimulates proliferation of embryonic cells."  Exp.Biol. Med. 230: 494-501.
    12. Halper J, Griffin A, Hu W, Jung C, Zhang J, Pan H, Kisaalita WS, Foutz TL, Frazier KS. 2005. "In vitro culture decreases the expression of TGFβ, Hsp47 and type I procollagen and increases the expression of CTGF in avian tendon explants."  J. Musculoskeletal & Neuronal Interactions 5:53-63.
    13. Yoon JH, Halper J. 2005."Tendon proteoglycans: biochemistry and function (perspective)." J. Musculoskeletal & Neuronal Interactions 5:22-34.
    14. Halper J, Burt DW, Romanoff MN. 2004. "On reassessment of the chicken TGFB4 gene as TGFB1."  Growth Factors 22:121-122.
    15. Yoon JH, Brooks R Jr, Zhao J-Z, Isaacs D, Halper J. 2004. "The effect of the fluoroquinolone enrofloxacin on avian tendon cell cultures."  Arch. Toxicol. 78:599-608.
    16. Yoon JH, Brooks RL Jr, Khan A, Pan H, Bryan J, Zhang J, Budsberg SC, Mueller POE, Halper J. 2004. "The effect of enrofloxacin on cell proliferation and proteoglycans in horse tendon cells." Cell Biol. Toxicol. 20:41-54.
    17. Halper J, Leshin LS, Lewis SJ, Li WI. 2003. "Wound healing and angiogenic properties of supernatants from Lactobacillus cultures." Exp. Biol. Med. 228:1329-1337.
    18. Pan H, Halper J. 2003. "Cloning, expression and characterization of chicken transforming growth factor β4."  Biochem. Biophys. Res. Comm. 303:24-30.
    19. Yoon HJ, Brooks R, Kim YH, Terada M, Halper J. 2003. "Proteoglycans in chicken gastrocnemius tendons change with exercise."  Arch. Biochem. Biophys. 412:279-286.
    20. Pan H, Halper J. 2003. "Regulation of heat shock protein 47 and type I procollagen expression in avian tendon cells."  Cell Tissue Res. 311:373-382.
    21. He Z, Ong C, Halper J, Bateman A. 2003. "Progranulin is a mediator of the wound response."  Nature Medicine 9: 225-229.
    22. Yoon JH, Brooks R Jr, Halper J. 2002. "Immunoblotting assays for keratan sulfate."  Anal. Biochem. 306:298-304.
    23. Daniel R, He Z, Carmichael KP, Halper J, Bateman A. 2000. "Cellular localization of gene expression for progranulin."  J. Histochem. Cytochem. 48:999-1010.
    24. Carter BJ, Halper J. 1996. "Transforming growth factor type e is a novel mediator of wound repair."  Wound. Repair. Regen. 4:100-109.
    25. Jung C, Parnell PG, Carter BJ, Harkins RG, Slattery TK, Halper J. 1995. "Characterization of antibodies to transforming growth factor type e and their use in immunolocalization of this growth factor."  Cell Vision 2:468-476.
    26. Parnell PG, Carter BJ, Halper J. 1995. "Identification of a membrane-associated receptor for transforming growth factor type e."  J. Receptor Signal Transduction Res. 15:747-756.
    27. Ren P, Scheithauer BW, Halper J. 1994. "The immunohistological localization of TGFα, EGF, IGF-I and TGFβ in normal human pituitary gland."  End. Pathol. 5:40-48.
    28. Parnell PG, Carter BJ, Halper J. 1993. "Purification of epithelial-type transforming growth factor by micro-preparative electrophoresis chromatography." BioTechniques 14:591-594.
    29. Halper J, Parnell PG, Carter B, Ren P, Scheithauer BW. 1992. "Presence of growth factors in the human pituitary."  Lab. Invest. 66:639-645.
    30. Parnell PG, Wunderlich J, Carter B, Halper J. 1992. "Transforming growth factor type-e: amino acid analysis and partial amino acid sequence."  Growth Factors 7:65-72.
    31. Brown CA, Halper J. 1990. "Mitogenic effects of transforming growth factor type e on epithelial and fibroblastic cell lines: comparison with other growth factors."  Exp. Cell. Res. 190:233-242.
    32. Halper J. 1990. "Specific binding of [3H]heparin to human carcinoma SW-13 and other mammalian cells."  Exp. Cell. Res. 187:324-327.
    33. Parnell PG, Wunderlich J, Carter BJ, Halper J. 1990. "Purification of transforming growth factor type e."  J. Cell. Biochem. 42:111-116.
    34. Halper J, Colvard DC, Scheithauer BW, Jiang NS, Press MF, Graham ML, Riehl E, Laws ER Jr, Spelsberg TC.1989. "Estrogen and progesterone receptors in meningiomas: Comparison of nuclear binding, dextran-coated charcoal and immunoperoxidase staining assays."  Neurosurgery 25:546-553.
    35. Halper J, Carter BJ. 1989. "Modulation of growth of carcinoma SW-13 cells by heparin and growth factors."  J. Cell. Physiol. 141:16-23.
    36. Halper J, Moses HL. 1987." Purification and characterization of a novel transforming growth factor."  Cancer Res. 47:4552-4559.
    37. Halper J, Scheithauer BW, Okazaki H, Laws ER Jr. 1986. "Meningio-angiomatosis: Report of six cases with special reference to the occurrence of neurofibrillary tangles."  J. Neuropathol. Exp. Neurol. 45:426-446.
    38. Moses HL, Tucker RF, Leof EB, Coffey RJ Jr, Halper J, Shipley GD. 1985. "Type ß transforming growth factor is a growth stimulator and a growth inhibitor."  Cancer Cells 3:65-71.