Leslie Petch Lee, PhD

  • AU/UGA Medical Partnership

    Campus Associate Dean for Campus Integration and Academic Enhancement

  • AU/UGA Medical Partnership

    Director of Phase I/II Curriculum

Leslie Petch Lee, PhD serves as Campus Associate Dean for Campus Integration and Academic Enhancement and Director of the Phase I/II Curriculum and Module Director at the AU/UGA Medical Partnership. Lee is also an adjunct Assistant Professor in the Department of Biochemistry, Medical College of Georgia. Lee earned her PhD at the University of North Carolina at Chapel Hill.

Education

1982 Bachelor of Science Biology Trinity College
1991 PhD Pharmacology University of North Carolina at Chapel Hill
Postdoctoral Cell adhesion-mediated signaling University of North Carolina at Chapel Hill

Academic Appointments

2015 - 2016 Interim Campus Dean
2010 - Present Assistant Dean for Curriculum, Phase 1 and 2 Curriculum Coordinator and Module Director, AU/UGA Medical Partnership
2008 - Present Adjunct Assistant Professor, Department of Biochemistry, Medical College of Georgia, Georgia Regents University
2008 - 2010 Phase 1 and 2 Curriculum Coordinator, Module Director, AU/UGA Medical Partnership
2005 - 2008 Assistant to the Provost, University of Georgia
1999 - 2005 Associate Director, Molecular Virology Core Facility, UNC Center for AIDS Research

More About Leslie Lee

Lee received her PhD in Pharmacology from the University of North Carolina at Chapel Hill (UNC-CH), where she also received postdoctoral training in Cell Biology. During her graduate and postdoctoral training she studied extracellular growth factors and cellular adhesion initiated signaling pathways involved in the regulation of cell growth and proliferation. Lee was the first to demonstrate soluble, extracellular forms of the Epidermal Growth Factor Receptor.  As a postdoctoral fellow, she identified the adaptor protein p130-Cas as a substrate for adhesion-mediated tyrosine phosphorylation and signaling.  Following postdoctoral training, Lee was appointed Associate Director of the Molecular Virology Core facility of UNC-CH’s Center for AIDS Research. In this capacity Lee contributed to numerous national and international basic and clinical studies on HIV drug resistance and response to therapy.

Lee joined the Provost’s Office at the University of Georgia in 2005. As Assistant to the Provost, Lee was responsible for facilitating and promoting interdisciplinary research initiatives, contributing to the planning and implementation of an Ecology of Infectious Diseases initiative that brought together investigators from the Odum School of Ecology, the Biomedical Health Sciences Institute, the College of Veterinary Medicine, the College of Public Health as well as various basic science departments in the College of Arts and Sciences. In addition she worked with UGA’s Research Office to help develop a faculty research expertise database to facilitate faculty interactions on campus. In 2007 Lee became involved in the early planning and development of the AU/UGA Medical Partnership and in 2008 was appointed Phase 1/2 Curriculum Coordinator for the Medical Partnership. She became Assistant Dean for Curriculum in 2010.  As Assistant Dean she oversees the development and implementation of the Phase 1/2 curriculum at the Medical Partnership. Lee also represents the Medical Partnership on the Medical College of Georgia Instructional Technology Advisory Committee, the Phase 1/2 Curriculum Committee, the Curriculum Oversight Committee and the Admissions Committee.

  • Expertise & Interests

    • Medical Education
    • Growth factor and cell adhesion-mediated signaling
    • HIV genotyping and drug resistance
  • Selected Publications

    • Harden, T.K., Petch, L.A., Traynelis, S.F., and Waldo, G.L.  Agonist induced alteration in the membrane form of muscarinic cholinergic receptors.  J. Biol. Chem. 260:13060-13066, 1985.
    • Silva, C.M., Tully, D.B., Petch, L.A., Jewell, C.M., and Cidlowski, J.A.  Application of a protein blotting procedure to the study of human glucocorticoid receptor interactions with DNA.  Proc. Natl. Acad. Sci. USA  84:1744-1748, 1987.
    • Earp, H.S., Hepler, J.R., Petch, L.A., Miller, A., Berry, A.R., Raymond, V.W., McCune, B.K., Lee, L.W., Grisham, J.W., and Harden, T.K.  Epidermal growth factor (EGF) and hormones stimulate phosphoinositide hydrolysis and increase EGF-receptor protein synthesis and mRNA levels in rat liver epithelial cells: Evidence for protein kinase C-dependent and independent pathways.  J. Biol. Chem.  263:13868-13874, 1988.
    • Petch, L.A., Harris, J., Raymond, V.W., Blasband, A., Lee, D.C., and Earp, H.S.  A truncated, secreted form of the epidermal growth factor receptor is encoded by an alternatively spliced transcript in normal rat tissue.  Mol. Cell. Biol.  10:2973-2982, 1990.
    • Earp, S., Huckle, W., Raymond, V., Petch, L., Marts, S., Bishop, W., and McCune B.  The epidermal growth factor receptor: control of synthesis and signaling function. In Growth Factors and Reproduction, David W. Schomberg ed., Springer-Verlag, pp. 3-22, 1991.
    • Petch, L.A., Bishop, W., Lee, D.C., and Earp, H.S. Truncated forms of the rat epidermal growth factor receptor. In: Mechanisms of Hepatic Endocytosis. Zuckschwerdt Publishers, San Francisco, 27 pgs.
    • Lee, D.C., Luetteke, N.C., and Petch, L.A. Transforming growth factor-a and its role in neoplastic progression. In: Oncogenes and Tumor Suppressor Genes in Human Malignancy, Benz,C. and Liu, E., eds., Kluwer Academic Publishers, Boston, 35 pgs.
    • Burridge, K., Petch, L.A., and Romer, L.H. Signals from Focal Adhesions. Curr. Biol. 2: 537-539, 1992.
    • Petch, L.A., Bockholt, S., Bouton, A., Parsons, J.T., and Burridge, K.B. Adhesion-induced tyrosine phosphorylation of the p130 src substrate.  J. Cell Sci. 108: 1371-1379, 1995.
    • Kinch, M.K., Petch, L., Zhong, C., and Burridge, K.  E-Cadherin engagement stimulates tyrosine phosphorylation. Cell Adh. Commun. 4: 425-43, 1997.
    • Arthur, W.T., Petch, L.A., and  Burridge, K.  Integrin engagement suppresses Rho‑A activity via a c-Src-dependent mechanism. Curr. Biol. 10(12): 719-22, 2000.
    • Schoenwaelder, S.M., Petch, L.A., Williamson, D., Shen, R., Feng, G-S., and Burridge, K.  The Protein-Tyrosine Phosphatase Shp-2 Regulates RhoA activity. Curr. Biol. 10(23): 1523-6, 2000.
    • Reddy Y.S., Gotzkowsky S.K., Eron J.J., Kim J.Y., Fiske W.D., Fiscus S.A., Petch L., Cohen M.S., and Kashuba A.D.  Pharmacokinetic and pharmacodynamic investigation of efavirenz in the semen and blood of human immunodeficiency virus type 1-infected men. J Infect Dis.  186(9): 1339-43, 2002.
    • Min S.S., Corbett A.H., Rezk N., Cu-Uvin S., Fiscus S.A., Petch L., Cohen M.S., and Kashuba A.D. Protease Inhibitor and Non-nucleoside Reverse Transcriptase Inhibitor concentrations in the genital tract of HIV-1-infected women. J Acquir Immune Defic Syndr.  15: 1577-1580, 2004. 
    • L.A. Petch, Hoffman, I.F., Jere C.S., Kazembe P.N., Martinson F.E., D.Chilongozi, Fiscus  S.A. and Cohen M.S. Genotypic Analysis of the Protease and Reverse Transcriptase of HIV-1 Subtype C Isolates from Antiretroviral Drug-Naïve Adults in Malawi. AIDS Res and Hum Retroviruses. 21(9): 57-63, 2005.
    • Fiscus S.A., Kovacs A., Petch L.A., Hu C., Wiznia A.A., Mofenson LM, Yogev R, McIntosh K, Pelton SI, Napravnik S, Stanley K, and Nachman SA. Baseline resistance to nucleoside reverse transcriptase inhibitors fails to predict virologic response to combination therapy in children (PACTG 338). AIDS Res Ther. 4 (2), 2007
    • Haubrich RH, Jiang H, Swanstrom R, Bates M, Katzenstein D, Petch L, Fletcher CV, Fiscus SA, and Gulick RM, for the AIDS Clinical Trials Group Protocol 359 Team. Non-nucleoside phenotypic hypersusceptibility cut-point determination from ACTG 359. HIV Clin Trials 8 (2): 63-7, 2007.
    • Eron, J.J., Bosch R. J., Bettendorf D., Petch L., Fiscus S. and Frank I.for the AACTG 307 Protocol Team. The effect of lamivudine therapy and M184V on the antiretroviral activity of didanosine.  JAIDS  45 (2): 249-251, 2007.
    • Anderson, J.A., Jiang H., Ding X., Petch L., Journigan T., Fiscus S.A., Haubrich R., Katzenstein D., Gulick R.M. and Swanstrom R. for the ACTG 359 Protocol Team. Genotypic susceptibility scores and HIV-RNA responses in treatment experienced subjects with HIV-1 infection. AIDS Res and Hum Retroviruses. 24(5):685-94, 2008
  • Of Note

    Dr. Lee was born and raised in South America and is fluent in Spanish.