Clive A. Slaughter, PhD
AU/UGA Medical Partnership
Professor of Biochemistry
Clive Slaughter, PhD serves as a teacher of biochemistry at the AU/UGA Medical Partnership, Athens GA. He earned his PhD degree from the University of London.
|1973||BS Zoology||University College London|
|1976||PhD Human Genetics||University College London|
|1976-1980||Postdoctoral Training||University of Pennsylvania|
|1980-1984||Postdoctoral Training||University of Texas Southwestern Medical Center|
|1984-1986||Senior Staff Investigator & Section Head of Protein Chemistry Section, Cold Springs Harbor Laboratory, New York|
|1986-1989||Assistant Investigator, Howard Hughes Medical Institute|
|1989-2000||Research Assistant Professor of Biochemistry, University of Texas Southwestern Medical Center at Dallas|
|2000-2007||Assistant Director, Hartwell Center for Bioinformatics and Biotechnology, St. Jude Children's Research Hospital, University of Tennessee at Memphis|
|2000-2009||Member, Department of Molecular Biotechnology, St. Jude Children's Research Hospital, University of Tennessee at Memphis|
|2001-2009||Associate Professor, Department of Pathology, University of Tennessee at Memphis|
|2003-2009||Associate Professor, Department of Molecular Sciences, University of Tennessee at Memphis|
|2009-Present||Associate Professor of Biochemistry and Medical Educator, AU/UGA Medical Partnership|
More About Clive Slaughter
Slaughter received his Ph.D. in Human Biochemical Genetics from University College London, U.K., then emigrated to the U.S.A. to complete postdoctoral training in Human Genetics at the University Pennsylvania, Philadelphia, PA and in Immunology at the University of Texas Southwestern Medical Center at Dallas, TX. He then embarked on a career in molecular biotechnology, managing advanced facilities for analysis and synthesis of biological macromolecules at Cold Spring Harbor Laboratory, NY, the University of Texas Southwestern Medical Center at Dallas, TX, and St. Jude Children’s Research Hospital, Memphis TN. He has performed research on intracellular protein degradation, and has contributed to the research of, and co-authored publications with, many eminent investigators, including six Nobel Prize winners. He has long been dedicated to teaching, which he began at Southwestern Medical Center in 1986, continued at the University of Tennessee at Memphis, TN, and now undertakes full-time at AU/UGA Medical Partnership at Athens, GA.
Expertise & Interests
- Molecular Biotechnology
- Protein Biochemistry
McCutchen-Maloney SL, Matsuda K, Shimbara N, Binns DD, Tanaka K, Slaughter CA, and DeMartino GN. 2000. cDNA cloning, expression, and functional characterization of P131, a proline-rich inhibitor of the proteasome. J. Biol. Chem. 275: 18557-18565.
Deng L, Wang C, Spencer E, Yang L, Braun A, You J, Slaughter C, Pickart C, and Chen ZJ. 2000. Activation of the Ikb kinase complex by TRAF6, requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. Cell 103: 351-361.
Kaufman BA, Newman SM, Hallberg RL, Slaughter CA, Perlman PS, and Butow RA. 2000. In organello formaldehyde crosslinking of proteins to mtDNA: identification of bifunctional proteins. Proc. Natl. Acad. Sci. (USA) 97:7772-7777.
van Oers NSC, Tohlen B, Malissen B, Moomaw CR, Afendis S, Slaughter CA. 2000. The 21- and 23-kD forms of TCRx are generated by specific ITAM phosphorylations. Nature Immunology 1:322-328.
Valkova-Valchanova M, Darrouzer E, Moomaw CR, Slaughter CA, Daldal F. 2000. Proteolytic cleavage of the Fe-S subunit hinge region of Rhodobacter capsulatus bc1, complex: effects of inhibitors and mutations. Biochemistry 39:15484-92.
Dahl SW, Slaughter C, Lauritzen C, Bateman RC, Connerton I, Pedersen J. 2000. Carica papaya glutamine cyclotransferase belongs to a novel plant enzyme subfamily: cloning and characterization of the recombinant enzyme. Protein Expression and Purification 20:27-36.
Ramsland PA, Shan L, Moomaw CR, Slaughter CA, Fan Z-C, Guddat LW, Edmundson AB. 2000. An unusual human IgM antibody with a protruding HCDR3 and high avidity for its ligands. Mol. Immunol. 37:295-310.
Trembley JH, Hu D, Hsu L-C, Yeung C-Y, Slaughter C, Lahti JM, Kidd VJ. 2002. PITSLRE p110 protein kinases associate with transcription complexes and effect their activity. J. Biol. Chem., 277:2589-2596.
Nathwani AC, Davidoff AM, Hanawa H, Hu Y, Hoffer FA, Nikanorav A, Slaughter C, Ng CYC, Zhou J, Lozier JN, Mandrell TD, Vanin EF, Nienhuis AW. 2002. Sustained high level expression of human FIX following liver targeted delivery of recombinant adeno-associated virus encoding the human FIX gene in rhesus macaques. Blood, 100:1662-9.
Trembley JH, Hu D, Slaughter CA, Lahti JM, Kidd VJ. 2003. Casein kinase 2 interacts with cyclin-dependent kinase11 in vivo and phosphorylates both the RNA polymerase II carboxy-terminal domain and CDK11 in vitro. J. Biol. Chem. 278:2265-2270.
Gallagher ED, Xu S, Moomaw C, Slaughter CA, Cobb MH. 2002. Binding of JNK/SAPK to MEKK1 is regulated by phosphorylation. J. Biol. Chem. 277:45785-45792.
Bencsath KP, Podgorski M, Meluh PB, Pagala VR, Slaughter CA, Schulman BA. (2002) Identification of a multifunctional binding site on Ubc9p required for Smt3p conjugation. J. Biol. Chem. 49:47938-47945.
Brown V, Krynetski EY, Krynetskaia NF, Grieger D, Mukatira ST, Murti KG, Slaughter CA, Park H-W, Evans WE. (2004) A novel CRM-1-mediated nuclear export signal governs nuclear accumulation of glyceraldehydes-3-phosphate dehydrogenase following genotoxic stress. J. Biol. Chem. 279:5984-5992.
Huang Y, Magdaleno S, Hopkins R, Slaughter C, Curran T, Keshvara L. (2004) Tyrosine phosphorylated disabled 1 recruits Crk family adapter proteins. Biochem. Biophys. Res. Comm. 318:204-212.
Trembley JH, Tatsumi S, Sakashita E, Loyer P, Slaughter CA, Suzuki H, Endo H, Kidd VJ, Mayeda A. (2005) Activation of pre-mRNA splicing by human RNPS1 is regulated by CK2 phosphorylation. Mol. Cell. Biol. 25:1446-1457.
Brown SA, Lockey TD, Slaughter C, Slobod KS, Surman S, Zirkel A, Mishra A, Pagala VR, Coleclough C, Doherty PC, Hurwitz JL. (2005) T cell epitope “hotspots” on the HIV type 1 gp120 envelope protein overlap with tryptic fragments displayed by mass spectrometry. AIDS Res Hum Retroviruses 21:165-170.
Bourne PC, Ramsland PA, Shan L, Fan Z-C, DeWitt CR, Shultz BB, Terzyan SS, Moomaw CR, Slaughter CA, Guddat LW, Edmundson AB. (2002) Three-dimensional structure of an immunoglobulin light-chain dimer with amyloidogenic properties. Acta Cryst. D58:815-823.
Alappat EC, Feig C, Volkland J, Boyerinas B, Samuels M, Murmann AE, Thorburn A, Kidd VJ, Slaughter CA, Osborn SL, Winoto A, Tang W-J, Peter ME. (2005) Phosphorylation of FADD at serine 194 by CKIα regulates its nonapoptotic activities. Mol. Cell, 19:321-332.
Ramsland PA, Terzyan SS, Cloud G, Bourne CR, Farrugia W, Tribbick G, Geysen HM, Moomaw CR, Slaughter CA, Edmundson AB. (2006) Crystal structure of a glycosylated Fab from an IgM cryoglobulin with properties of a natural proteolytic antibody. Biochemical Journal 395:473-481.
Dickerson JB, Morgan MA, Mishra A, Slaughter CA, Morgan JI, Zheng J. (2006) The influence of phosphorylation on the activity and structure of the neuronal IQ motif protein, PEP-19. Brain Research 1092:16-27.
Galea CA, Pagala VR, Obenauer JC, Park C-G, Slaughter CA, Kriwacki RW. (2006) Proteomic studies of the intrinsically unstructured mammalian proteome. J. Proteome Res. 5:2839-2848.
Robbins BL, Poston PA, Neal EF, Slaughter C, Rodman JH. (2007) Simultaneous measurement of intracellular triphosphate metabolites of zidovudine, lamivudine and abacavir (carbovir) in human peripheral blood mononuclear cells by combined anion exchange solid phase extraction and LC-MS/MS. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 850:310-7.
Galea CA, High A, Obenauer J, Mishra A, Park C-G, Puntas M, Schlessinger A, Rost B, Slaughter CA, Kriwacki R. (2009) Large-scale analysis of thermostable, mammalian proteins provides Insights into the mammalian intrinsically disordered proteome. J. Proteome Res. 8:211-226.
Gilette TG, Kumar B, Thompson D, Slaughter CA, DeMartino GN. (2008) Differential roles of the COOH termini of AAA subunits of PA700 (19 S regulator) in asymmetric assembly and activation of the 26 S proteasome. J. Biol. Chem. 283:31813-31822.
Zhou J, Wu R, High AA, Slaughter CA, Finkelstein D, Rehg JE, Redecke V, Häcker H. A20-binding inhibitor of NF-κB (ABIN1) controls Toll-like receptor-mediated CCAAT/enhancer-binding protein β activation and protects from inflammatory disease. Proc Natl Acad Sci U.S.A. 108;2011:E998-E1006.
Zhou J, Wu R, High AA, Slaughter CA, Finkelstein D, Rehg JE, Redecke V, Häcker H. A20-binding inhibitor of NF-κB (ABIN1) controls Toll-like receptor-mediated CCAAT/enhancer-binding protein β activation and protects from inflammatory disease. Author Summary. Proc Natl Acad Sci U.S.A. 108;2011:17869-17870.
Slaughter is active in the Progressive Church Movement in the U.S., and has worked extensively with peace and justice groups. His own activities have focused on work with homeless persons and asylum seekers.