Phillip Holmes, PhD
Phillip Holmes, PhD
Professor of Neuroscience
Psychology Building 616, 125 Baldwin Street Athens GA, 30602
Staff Fellow, Behavioral Neuropharmacology, National Institue of Mental Health Bethesda, Maryland, 1995
PhD, Brown University Providence, Rhode Island, 1992
ScM, Brown University Providence, Rhode Island, 1990
BA, University of Vermont Burlington, Vermont, 1986
Simone, J., Bogue, E.A., Bhatti, D.L., Day, L.E. Farr, N.A., Grossman, A. M., and Holmes, P.V. (2015) Ethinyl estradiol and levonorgestrel alter cognition and anxiety in rats concurrent with a decrease in tyrosine hydroxylase expression in the locus coeruleus and brain-derived neurotrophic factor expression in the hippocampus. Psychoneuroendocrinology, 62, 265-278.
Holmes, P. V., Reiss, J. I., Murray, P. S., Dishman, R. K., and Spradley, J. M. (2015). Chronic exercise dampens hippocampal glutamate overflow induced by kainic acid in rats. Behavioural Brain Research, 284, 19-23.
Sciolino, N. R., Smith, J. M., Stranahan, A. M., Freeman, K. G., Edwards, G. L., Weinshenker, D., and Holmes, P. V. (2015) Galanin mediates features of neural and behavioral stress resilience afforded by exercise. Neuropharmacology, 89, 255-264.
Ogbonmwan, Y. E., Schroeder, J. P., Holmes, P. V., and Weinshenker, D. (2015) The effects of post-extinction exercise on cocaine-primed and stress-induced reinstatement of cocaine seeking in rats. Psychopharmacology, 232, 1395-1403.
Ogbonmwan, Y.E., *Sciolino, N.R., Groves-Chapman, J.L., Freeman, K.G., Edwards, G.L., Holmes, P.V., and Weinshenker, D. (2015) The galanin receptor agonist galnon attenuates cocaine-induced reinstatement and dopamine overflow in the frontal cortex. Addiction Biology, 20. 701-713.
Monroe, D., Holmes, P., Koch, L., Britton, S., and Dishman, R. (2014) Striatal enkephalinergic differences in rats selectively bred for intrinsic running capacity. Brain Research, 1572, 11-17.
Epps, S.A., Kahn, A.B., Holmes, P.V., Boss-Williams, K.A., Weiss, J.M., Weinshenker, D. (2013) Antidepressant and anticonvulsant effects of exercise in a rat model of epilepsy and depression comorbidity. Epilepsy and Behavior, 29, 47-52.
Sciolino, N.R., Dishman, R.K., Holmes, P.V. (2012) Voluntary exercise offers anxiolytic potential and amplifies galanin gene expression in the locus coeruleus of the rat. Behavioral Brain Research, 233, 191-200.
Groves-Chapman, J.L., Murray, P.S., Stevens, K.L., Monroe, D.C., Koch, L.G., Britton, S.L., Holmes, P.V., Dishman, R.K. (2011) Changes in mRNA levels for brain-derived neurotrophic factor after wheel running in rats selectively bred for high- and low-aerobic capacity. Brain Research, 1425, 90-97.
R01 DA027535: National Institute on Drug Abuse, “Effects of voluntary exercise on reinstatement of cocaine seeking,” Principal Investigator, 2010-2015
R01 DA017963: National Institute on Drug Abuse, “Mechanism of disulfiram-induced cocaine abstinence”: Co-investigator, 2006-2008
R29 MH59317: National Institute of Mental Health, “Stress reactivity, depression, and neuropeptide-Y” Principal Investigator, 1998-2004
R03 DA12120: National Institute on Drug Abuse, “New model of drug abuse and depression comorbidity”: Principal Investigator, 1999-2001
R03 MH56415: National Institute of Mental Health, “Role of neuropeptide-Y in the olfactory bulbectomy syndrome”: Principal Investigator, 1996-1997
Scholarship & Research
Neurobiological Mechanisms Responsible for Stress Resilience and Regulation of Affective Motivation.