Phillip Holmes, PhD

Phillip Holmes, PhD

Phillip Holmes, PhD

Professor of Neuroscience

Psychology Building 616, 125 Baldwin Street Athens GA, 30602

706-542-3105

Education

Staff Fellow, Behavioral Neuropharmacology, National Institue of Mental Health Bethesda, Maryland, 1995

PhD, Brown University Providence, Rhode Island, 1992

ScM, Brown University Providence, Rhode Island, 1990

BA, University of Vermont Burlington, Vermont, 1986

Selected Publications

Simone, J., Bogue, E.A., Bhatti, D.L., Day, L.E. Farr, N.A., Grossman, A. M., and Holmes, P.V. (2015) Ethinyl estradiol and levonorgestrel alter cognition and anxiety in rats concurrent with a decrease in tyrosine hydroxylase expression in the locus coeruleus and brain-derived neurotrophic factor expression in the hippocampus.  Psychoneuroendocrinology, 62, 265-278.

Holmes, P. V., Reiss, J. I., Murray, P. S., Dishman, R. K., and Spradley, J. M. (2015). Chronic exercise dampens hippocampal glutamate overflow induced by kainic acid in rats. Behavioural Brain Research, 284, 19-23.

Sciolino, N. R., Smith, J. M., Stranahan, A. M., Freeman, K. G., Edwards, G. L., Weinshenker, D., and Holmes, P. V. (2015) Galanin mediates features of neural and behavioral stress resilience afforded by exercise. Neuropharmacology, 89, 255-264.

Ogbonmwan, Y. E., Schroeder, J. P., Holmes, P. V., and Weinshenker, D. (2015) The effects of post-extinction exercise on cocaine-primed and stress-induced reinstatement of cocaine seeking in rats. Psychopharmacology, 232, 1395-1403.

Ogbonmwan, Y.E., *Sciolino, N.R., Groves-Chapman, J.L., Freeman, K.G., Edwards, G.L., Holmes, P.V., and Weinshenker, D. (2015) The galanin receptor agonist galnon attenuates cocaine-induced reinstatement and dopamine overflow in the frontal cortex.  Addiction Biology, 20. 701-713.

Monroe, D., Holmes, P., Koch, L., Britton, S., and Dishman, R. (2014) Striatal enkephalinergic differences in rats selectively bred for intrinsic running capacity. Brain Research, 1572, 11-17.

Epps, S.A., Kahn, A.B., Holmes, P.V., Boss-Williams, K.A., Weiss, J.M., Weinshenker, D. (2013) Antidepressant and anticonvulsant effects of exercise in a rat model of epilepsy and depression comorbidity. Epilepsy and Behavior, 29, 47-52.

Sciolino, N.R., Dishman, R.K., Holmes, P.V. (2012) Voluntary exercise offers anxiolytic potential and amplifies galanin gene expression in the locus coeruleus of the rat.  Behavioral Brain Research, 233, 191-200.

Groves-Chapman, J.L., Murray, P.S., Stevens, K.L., Monroe, D.C., Koch, L.G., Britton, S.L., Holmes, P.V., Dishman, R.K. (2011) Changes in mRNA levels for brain-derived neurotrophic factor after wheel running in rats selectively bred for high- and low-aerobic capacity. Brain Research, 1425, 90-97.

Grant Support

R01 DA027535: National Institute on Drug Abuse, “Effects of voluntary exercise on reinstatement of cocaine seeking,” Principal Investigator, 2010-2015

R01 DA017963: National Institute on Drug Abuse, “Mechanism of disulfiram-induced cocaine abstinence”: Co-investigator, 2006-2008

R29 MH59317: National Institute of Mental Health, “Stress reactivity, depression, and neuropeptide-Y” Principal Investigator, 1998-2004

R03 DA12120: National Institute on Drug Abuse, “New model of drug abuse and depression comorbidity”: Principal Investigator, 1999-2001

R03 MH56415: National Institute of Mental Health, “Role of neuropeptide-Y in the olfactory bulbectomy syndrome”: Principal Investigator, 1996-1997

Scholarship & Research

Psychopharmacology

Neurobiological Mechanisms Responsible for Stress Resilience and Regulation of Affective Motivation.

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