Ken Rosenthal, PhD

Ken Rosenthal, PhD

Ken Rosenthal, PhD
Ken Rosenthal, PhD

Professor of Immunology

Russell Hall 157, 1425 Prince Avenue, Athens GA, 30602

706-713-2174

Education

BS Chemistry: University of Deleware, Newark Deleware, 1973

MA Biochemistry: University of Illinois, Urbana, Illinois, 1976

PhD Biochemistry: University of Illinois, Urbana, Illinois, 1977

Research Fellow, Tumor Virology:  Sidney Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, 1977 – 1979

Honors / Awards / Achievements

M2 Teacher of the Year, 2015, voted by Medical Students, Northeast Ohio Medical University (NEOMED)

Hooder for Graduation, Nominated by Classes 2011, 2012, and 2014, NEOMED College of Medicine

Phi Lamda Sigma Honorary Member, voted by Pharmacy Students Class of 2014, NEOMED

Visiting Professor for Microbiology and Immunology, American University of Antigua College of Medicine  2014

Emeritus Professor, 2013, NEOMED

Liebelt-Wheeler Faculty Excellence Award, 2013, NEOMED

Gender Equity Award, Nominated by Class of 2012, NEOMED

Course Director, Best M2 Course 2011 (Infection and Immunity), NEOMED

Master Teacher of the NEOMED Master Teacher’s Guild, 2010 – Present

Waksman Foundation for Microbiology Lecturer, American Society for Microbiology, 2005 – 2007

American Cancer Society Jr. Faculty Research Award, 1981 – 1984

American Cancer Society Postdoctoral Fellowship,  1977-1979

Selected Publications

Antimicrobials

Storm, D.R., Rosenthal, K.S. and Swanson, P.E.  1977. The Polymyxins and Related Peptide Antibiotics, Ann. Rev. Biochem. 46:723-763.

Rosenthal, K.S., Sokol, M.S., Ingram, R., Subramanian, R. and Fort, R.  1982. Tromantadine: An Inhibitor of Early and Late Events in HSV Replication. Antimicrob. Ag. Chemother. 22:1031-1036.  (Translated and reprinted into Spanish).

Walro, D.G. and Rosenthal, K.S.  1997. The Antiviral Xanthate Compound D609 Inhibits HSV-1 Replication and Protein Phosphorylation.  Antiviral Research 36:63-72.

Herpes Viruses

Rosenthal, K.S., Shapiro, H.M.  1983. Cell Membrane Potential Changes Following EBV Binding, J. Cell Physiol. 117:39-42.

Rosenthal, K.S., Leuther, M.D. and Barisas, B.G.  1984. HSV Binding and Entry Modulates Cell Surface Protein Mobility, J. Virol. 49:980-983.

Hodnichak, C.M., Turley-Shoger, E. and Rosenthal, K.S.  1984. Visualization of HSV-1 Attachment to Target Cells Using S. aureus as a Morphologic Tag, J. Virol. Meth. 8:191-198.

Bower, J.R., Mao, H. Durishin, C., Rozenbom, E., Detwiler, M., Rempinski, D., Karban, T.L. and Rosenthal, K.S.  1999. Intrastrain Variants of HSV-1 Isolated from a Neonate with Fatal Disseminated Infection Differ in the ICP34.5 Gene, Glycoprotein Processing, and Neuroinvasive Disease.  J. Virology 73:3843-3853.

Mao, H., Rosenthal, K.S. 2003.  Strain Dependent Structural Variants of Herpes Simplex Virus Type 1 ICP34.5 Determine Viral Plaque Size, Efficiency of Glycoprotein Processing and Viral Release and Neuroinvasive Disease Potential.  J. Virol. 77:3409-3417.

Artificial Pancreas

SF. Grundfest-Broniatowski , G Tellioglu, KS Rosenthal, J Kang, G Erdodi, B Yalcin, M Cakmak, J Drazba, A Bennett, L Lu, and J P Kennedy.  A new bioartificial pancreas utilizing amphiphilic membranes for the immunoisolation of porcine islets: a pilot study in the canine. ASAIO J. 2009 55(4):400-5.

Vaccines

Taylor, P.R., Paustian, C.C., Koski, G.K., Zimmerman, D.H., Rosenthal, K.S.. 2010. Maturation of dendritic cell precursors into IL12 producing DCs by J-LEAPS Immunogens. Cellular Immunology, 262: 1-5

Zimmerman, D.H., Taylor, P.R., Bendele, A., Carambula, R., Duzant, Y., Lowe, V., O’Neill, S.P., Talor, E., Rosenthal, K.S.. 2010. CEL-2000: A Therapeutic Vaccine for Rheumatoid Arthritis Arrests Disease Development and Alters Serum Cytokine / Chemokine Patterns in the Bovine Collagen Type II Induced arthritis  in the DBA Mouse Model, Intl Immunopharm. 10: 412-421

Taylor, P.R., Koski, G.K., Paustian, C.C., Bailey, E., Cohen, P.A., Moore, F.B-G., Zimmerman, D.H., Rosenthal, K.S. 2010.  J-LEAPS vaccines initiate murine Th1 responses by activating dendritic cells. Vaccine. 28: 5533–5542

Rosenthal KS, Mickecz K, Steiner H, Glant TT, Finnegan A, Carambula R, Zimmerman DH.2015. Rheumatoid arthritis vaccine therapies: Perspectives and lessons from therapeutic ligand epitope antigen presentation system vaccines for models of rheumatoid arthritis. Expert Review of Vaccines 14(6):1-18

Rosenthal KS, Stone S, Koski G, Zimmerman DH. 2017.  LEAPS Vaccine Incorporating HER-2/NEU Epitope Elicits Protection That Prevents and Limits Tumor Growth and Spread in a Mouse Model of Breast Cancer.  J. Immunology Research, Special Issue Cancer Vaccines. Volume 2017, Article ID 3613505, https://doi.org/10.1155/2017/3613505

K Mikecza, K., Glant, T.T., Markovics, A., Rosenthal, K.S., Kurko, J., Carambula, R.E., Cress, S., Steiner 3rd, H.L., Zimmerman, D.H. 2017. An epitope-specific DerG-PG70 LEAPS vaccine modulates T cell responses and suppresses arthritis progression in two related murine models of rheumatoid arthritis. Vaccine  35: 4048–4056. http://dx.doi.org/10.1016/j.vaccine.2017.05.009

Rosenthal, KS and Zimmerman DH. 2017. J-LEAPS vaccines elicit antigen specific Th1 responses by promoting maturation of type 1 dendritic cells (DC1). Part of a special issue on Dendritic Cells.  AIMS Allergy and Immunology. 1(2): 89-100 http://www.aimspress.com/article/10.3934/Allergy.2017.2.89

Education

Rosenthal, J., Rosenthal, K. 2017. Interactive Journal Club: Teaching an Old Dog New Tricks J Medical Education and Curricular Development. 4:1-6  https://journals.sagepub.com/doi/full/10.1177/2382120517719710

Lazerson J, Rosenthal J, Glaubensklee C, Hunt T, Morgenstern B, Pamidimukkala J, Penn DM, Rosenthal K, Sarsekeyeva M, Wragg S. 2018. Adaptation of the Roseman 6-Point Mastery Learning Model to the College of Medicine Program. Journal of Medical Education and Curricular Development Volume 5: 1–5.  http://journals.sagepub.com/doi/full/10.1177/2382120518803111

Grant Support

Previously supported by grants from NIH, foundations, and the pharmaceutical and biotech industry for studies of vaccines, antimicrobials, herpes simplex virus pathogenesis, and development of an artificial pancreas.

Educational Activities

Module Co-Director: Foundations Module, 2020

Module Co-Director: Hematology-Oncology, 2020

Large Group Instruction: Phase 2, Immunology of the Organ Systems

Small Group Facilitation: Phase 2

Pre-college science education

Scholarship & Research

Primary author and editor of Medical Micobiology, 1st through 8th editions, a successful textbook translated into many languages, and the 9th edition which will be published in March 2020.  Also, Rapid reviews of microbiology and immunology, 1st through 3rd editions (2010), Review of Medical Microbiology (2005), and Medical Microbiology And Immunology Flash Cards, (2005, 2009, 2017).

Research interests include the development of peptide vaccines for the prevention of viral infections and breast cancer and for treatment of breast cancer and rheumatoid arthritis using the LEAPS peptide vaccine platform; Studies of the pathogenesis of herpes simplex virus infections; Development and analysis of antimicrobial molecules.

A primary interest is making medical education fun.

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