Amy Medlock, PhD

Amy Medlock, PhD

Amy Medlock, PhD

Associate Professor of Biochemistry

Coverdell Center N235B, 500 D.W. Brooks Drive, Athens, GA 30602

706-542-7843

Education

Postdoctoral Fellow, University of Cape Town, South Africa, 2003 – 2004

Postdoctoral Associate, University of Georgia Athens, Georgia, 2001 – 2003, 2004 – 2009

PhD, Biochemistry, University of Georgia Athens, Georgia, 2000

BS, Chemistry, Erskine College, 1994

Honors / Awards / Achievements

Chair, Chemistry and Biology of Tetrapyrroles Gordon Research Conference, July 2022

Vice Chair, Chemistry and Biology of Tetrapyrroles Gordon Research Conference, July 2020

Discussion Leader, Chemistry and Biology of Tetrapyrroles Gordon Research Conference, July 2012 and 2016

Online Learning Fellow, University of Georgia, summer 2016

Outstanding Poster Presentation Award International Association of Medical Science Educators Annual Meeting June 2013

Southern Group on Educational Affairs 2013 Outstanding Poster Award for a professional educator April 2013

Selected Publications

The Mitochondrial Heme Metabolon: Insights into the Complex(ity) of Heme Synthesis and Distribution, R. B. Piel, III, H. A. Dailey, Jr. and A. E. Medlock, Molecular Genetics and Metabolism, 2019, pii: S1096-7192 (18), 30634-6.

Glutamine via α-ketoglutarate dehydrogenase provides succinyl-CoA for heme synthesis during erythropoiesis, J. S. Burch, J. R. Marcero, J. A. Maschek, J. E. Cox, L. K. Jackson, A. E. Medlock, J. D. Phillips, H. A. Dailey, Jr, Blood, 2018, 132 (10), 987-998.

Thoughts on interactions between PGRMC1 and diverse attested and potential hydrophobic ligands, M. A. Cahill and A. E. Medlock, Journal of Steroid Biochemistry and Molecular Biology, 2017, 171, 11-33.

*Heme Biosynthesis, A. E. Medlock and H.A. Dailey, chapter in Metalloprotein Active Site Assembly, 1st Ed., ed. Robert A. Scott and Michael K. Johnson, 2017, Wiley.

*A Novel Role for Progesterone Receptor Membrane Component 1 (PGRMC1): A Partner and Regulator of Ferrochelatase, R. B. Piel III, M. T. Shiferaw, A. A. Vashisht, J. Marcero, J. Praissman, J. Phillips, J. Wohlschlegel and A. E. Medlock, Biochemistry, 2016, 55 (37), 5204-5217.

*Identification of the Mitochondrial Heme Metabolism Complex, A. E. Medlock, M. T. Shiferaw, Jason R. Marcero, Ajay A. Vashisht, James A. Wohlschlegel, John D. Phillips, and Harry A. Dailey, PLoS One, 2015, 10(8):e0135896.

*Managing Micronutrient Nutrition: The Vitamin B12 Exemplar, A. Medlock, G. Crites , J. Stowe, MedEdPORTAL 2014. Available from:www.mededportal.org/publication/9771

Just-in-Time Teaching (JiTT): An Active Learning Pedagogy to Study Concepts in Cell Biology, V. T. Gaddy and A. E. Medlock, Med Sci Educ 2013, 23 (4), 664-665.

Mitochondrial Atpif1 regulates heme synthesis in developing erythroblasts, D. I. Shah, N. Takahashi-Makise, J. D. Cooney, L. Li, I. J. Schultz, E. L. Pierce, A. Narla, S. M. Hattangadi, A. E. Medlock, N. B. Langer, T. A. Dailey, S. N. Hurst, D. Faccenda, J. M. Wiwczar, S. K. Heggers, G. Vogin, W. Chen, C. Chen, D. R. Campagna, C. Brugnara, Y. Zhou, B. L. Elbert, N. N. Danial, M. D. Fleming, D. M. Ward, M. Campanella, , H. A. Dailey, J. Kaplan, and B. H. Paw, Nature 2012, 491(7425), 608-612.

*Identification and Characterization of Solvent-Filled Channels in Human Ferrochelatase, A. E. Medlock,W. Najahi-Missaoui, T. A. Ross, T. A. Dailey, J. Burch, J. R. O’Brien, W. N. Lanzilotta and H. A. Dailey, Biochemistry 2012, 51 (27), 5422-5433.

Grant Support

Research Project Grant (PA-19-056), NIH, R01, Role Co-PI, “Mechanisms of Mitochondrial Heme Transport”, September 2019-August 2024, $625,000 – pending

Center for Heme and Iron Disorders Pilot and Feasibility Grant, University of Utah Center for Excellence, Role PI, “Creation of Transgenic Zebrafish with Erythroid Expressed Heme Sensors”, September 2018-October 2019, $30,000 – funded

New Directions in Hematology Research (SHINE-II) Program (PAS-15-168), NIH, R01, Role PI, “Identifying the Function of the Mitochondrial Heme Biosynthesis Complex in Erythropoiesis”, May 2017-April 2020, $400,000 – funded

Center for Heme and Iron Disorders Pilot and Feasibility Grant, University of Utah Center for Excellence, Role PI, “Creation and Characterization of PGRMC1 and PGRMC2 Null Model Systems”, January 2017-December 2017, $25,000 – completed

Faculty Research Grant, University of Georgia, Office of the Vice President for Research, Role PI, “Defining the Roles of Progesterone Receptor Membrane Component 1 and 2 in

Heme Homeostasis”, July 2015-June 2016, $10,000 – completed

Provost Summer Research Funds, University of Georgia, Office of the Provost, Role PI, “Role of Progesterone Receptor Membrane Component 1 in Erythropoiesis”, June 2014-August 2014, $5,000 – completed

Grant-in-Aid, American Heart Association, Greater Southeastern Affiliate, Role PI, “Total Body Heme Homeostasis in Zebrafish”, July 2012-December 2014, $165,000 – completed

Scholarship & Research

Heme Biosynthesis

Heme Trafficking

Erythropoiesis

Biochemistry Education

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